Ultrathin Niobium Carbide MXenzyme for Remedying Hypertension by Antioxidative and Neuroprotective Actions.

Hypertension, as a leading risk factor for cardiovascular diseases, is associated with oxidative stress and impairment of endogenous antioxidant mechanisms, but the tremendous knowledge gap between hypertension treatment and nanomedicine is present at current stage. Herein, we report a specific nanozyme based on ultrathin two-dimensional (2D) niobium carbide (Nb2C) MXene, termed as Nb2C MXenzyme, to fight against hypertension by achieving highly efficient reactive oxygen species elimination and inflammatory factors inhibition. The biocompatible Nb2C MXenzyme is featured with multiple enzyme-mimicking activities, involving superoxide dismutase, catalase, glutathione peroxidase, and peroxidase, inducing cytoprotective effects by resisting oxidative stress, thereby alleviating inflammatory response and reducing blood pressure, which is systematically demonstrated in the stress-induced hypertension rat model. This strategy not only opens new opportunities for nanozyme to treat hypertension; but also expands the potential biomedical applications of 2D MXene nanosystems.