Diane-35 and metformin therapy in rats with endometrial lesions induced by dihydrotestosterone exposure.

Yanjun Liu,Ran Xu,Yifan Zhou,Yang Wang,Feifei Zhang,Xiaoyu Tong,Peng Cui,Tong Ma,Jian Sun,Yi Feng,Xin Li

Annals of translational medicine（2023）

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摘要

Hyperandrogenism and insulin resistance likely play important roles in the pathophysiological changes of PCOS and lead to PCOS-like characteristics as well as endometrial lesions. Hypoandrogenic and insulin sensitization therapy can alleviate DHT-induced endometrial hyperplasia by regulating AR and GLUT4 expression.

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关键词

CUBIC 3-dimensional tissue clearing,Diane-35,endometrium,metformin,polycystic ovary syndrome (PCOS)

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