Macrophage contribution to the survival of transferred expanded skin flap through angiogenesis.
Annals of translational medicine(2023)
Abstract
Alternatively activated macrophages in the expanded flap could significantly promote angiogenesis, improve blood perfusion, and ultimately increase the flap survival rate. Modulating alternatively activated macrophages may provide a key therapeutic strategy to promote expanded skin flap survival. Our study has provided a basis for clinically improving random-pattern skin flap survival.
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Key words
Tissue expansion,angiogenesis,macrophages,random-pattern flap,survival
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