Pediatric phase 2 trial of a WEE1 inhibitor, adavosertib (AZD1775), and irinotecan for relapsed neuroblastoma, medulloblastoma, and rhabdomyosarcoma.

Kristina A Cole,Heba Ijaz,Lea F Surrey,Mariarita Santi,Xiaowei Liu,Charles G Minard,John M Maris,Stephan Voss,Joel M Reid,Elizabeth Fox,Brenda J Weigel

Cancer（2023）

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摘要

This is first phase 2 clinical trial of adavosertib in pediatrics and the first with irinotecan. The combination may be of sufficient activity to consider further study of adavosertib in neuroblastoma.

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关键词

AZD1775,WEE1,adavosertib,alternative lengthening of telomeres (ALT),irinotecan,pediatric cancer

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