Cationic Ester Prodrugs of Curcumin with N,N-dimethyl Amino Acid Promoieties Improved Poor Water Solubility and Intestinal Absorption.

Mariko Hirano-Kusuda,Shuichi Setoguchi,Mitsuhisa Koga, Shotaro Goto,Ayano Yamada,Daisuke Watase,Nami Nagata-Akaho,Yoshiharu Karube, Kazuhisa Matsunaga,Jiro Takata

Pharmaceutical research（2023）

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摘要

The cationic N,N-dimethyl amino acid ester prodrugs of Cur improved the water solubility of Cur and enhanced oral bioavailability in rats. These Cur prodrugs may be good candidates for developing medicinal options previously unavailable due to the poor water solubility and oral BA of Cur.

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关键词

bioavailability,curcumin,drug delivery system,prodrug,rat

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