Orthogonal engineering of synthetic T cell states to enhance cancer immunotherapy

Nature immunology（2023）

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摘要

Orthogonal engineering of adoptively transferred CD8 + T cells to co-express two cytokines — an IL-2Rβ/γ-biased IL-2 variant and the proinflammatory alarmin IL-33 — induces an exhaustion-resistant synthetic cell state with potent anti-tumor efficacy in the absence of host pre-conditioning.

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关键词

Applied immunology,Tumour immunology,Biomedicine,general,Immunology,Infectious Diseases

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