Combination chemo-immunotherapy in advanced oesophageal squamous cell carcinoma.

Advanced oesophageal squamous cell carcinoma remains an important therapeutic challenge due to the paucity of established treatment options 1 Janmaat VT Steyerberg EW van der Gaast A et al. Palliative chemotherapy and targeted therapies for esophageal and gastroesophageal junction cancer. Cochrane Database Syst Rev. 2017; 11CD004063 PubMed Google Scholar and high prevalence of comorbidities. Cytotoxic chemotherapy has been the main treatment option for systemic spread because it can delay disease progression and prolong life in selected patients. 2 Muro K Lordick F Tsushima T et al. Pan-Asian adapted ESMO Clinical Practice Guidelines for the management of patients with metastatic oesophageal cancer: a JSMO-ESMO initiative endorsed by CSCO, KSMO, MOS, SSO and TOS. Ann Oncol. 2019; 30: 34-43 Summary Full Text Full Text PDF PubMed Scopus (83) Google Scholar , 3 Ajani JA D'Amico TA Bentrem DJ et al. Esophageal and esophagogastric junction cancers, version 2.2019, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2019; 17: 855-883 Crossref PubMed Scopus (476) Google Scholar Other treatments, such as radiotherapy, are also appropriate to palliate symptoms, particularly dysphagia. 3 Ajani JA D'Amico TA Bentrem DJ et al. Esophageal and esophagogastric junction cancers, version 2.2019, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2019; 17: 855-883 Crossref PubMed Scopus (476) Google Scholar Tislelizumab plus chemotherapy versus placebo plus chemotherapy as first-line treatment for advanced or metastatic oesophageal squamous cell carcinoma (RATIONALE-306): a global, randomised, placebo-controlled, phase 3 studyTislelizumab plus chemotherapy as a first-line treatment for advanced or metastatic oesophageal squamous cell carcinoma provided superior overall survival with a manageable safety profile versus placebo plus chemotherapy. Given that the interim analysis met its superiority boundary for the primary endpoint, as confirmed by the independent data monitoring committee, this Article represents the primary study analysis. Full-Text PDF