The influence of BCL2, BAX, and ABCB1 gene expression on prognosis of adult de novo acute myeloid leukemia with normal karyotype patients.

Zlatko Pravdic,Nada Suvajdzic Vukovic,Vladimir Gasic,Irena Marjanovic,Teodora Karan-Djurasevic,Sonja Pavlovic,Natasa Tosic

Radiology and oncology（2023）

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摘要

The present analysis of , and gene expression profiles is the first study focusing solely on AML-NK patients. Preliminary results showed that patients with high expression are likely to experience resistance to chemotherapy, and may benefit from specific anti-BCL2 treatment. Further investigations conducted on a larger number of patients could elucidate actual prognostic significance of these genes in AML-NK patients.

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关键词

ABCB1,BAX,BCL2,BCL2/BAX ratio,acute myeloid leukemia with normal karyotype,prognosis

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