Exercise Reduces Airway Smooth Muscle Contraction in Asthmatic Rats via Inhibition of IL-4 Secretion and Store-Operated Ca 2+ Entry Pathway.

Allergy, asthma & immunology research(2023)

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摘要
The data in this study reveal that aerobic exercise may improve the ASM contractile function in asthmatic rats by inhibiting IL-4 secretion and by down-regulating the expression of STIM1, Orai1 and Orai2, thus decreasing excessive SOCE-mediated ASM contraction in asthmatic rats.
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关键词
airway,asthma,calcium release activated calcium channels,exercise,interleukin 4,smooth muscle
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