Exploration of a Potential DOOR Endpoint for Complicated Intra-Abdominal Infections Using Nine Registrational Trials for Antibacterial Drugs.

Tori Kinamon,Ramya Gopinath,Ursula Waack,Mark Needles,Daniel Rubin,Deborah Collyar,Sarah B Doernberg, Scott Evans,Toshimitsu Hamasaki,Thomas L Holland,Jessica Howard-Anderson,Henry Chambers,Vance G Fowler,Sumati Nambiar,Peter Kim,Helen W Boucher

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America（2023）

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摘要

We designed and evaluated a potential DOOR endpoint for cIAI trials to further characterize overall clinical experiences of participants. Similar data-driven approaches can be utilized to create other infectious disease-specific DOOR endpoints.

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关键词

DOOR,Intraabdominal infection,antimicrobial therapy,clinical trials,endpoints

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