Population pharmacokinetics and target attainment analyses to identify a rational empirical dosing strategy for cefepime in critically ill patients.

Guohua An,C Buddy Creech,Nan Wu,Roger L Nation,Kenan Gu,Demet Nalbant,Natalia Jimenez-Truque,William Fissell,Pratish C Patel,Nicholas Fishbane,Amy Watanabe,Stephanie Rolsma,Carl M J Kirkpatrick,Cornelia B Landersdorfer,Patricia Winokur

The Journal of antimicrobial chemotherapy（2023）

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摘要

Continuous infusion may represent a promising strategy for cefepime treatment in critically ill patients. With the availability of institution- and/or unit-specific cefepime susceptibility patterns as well as individual patients' renal function, our PTA results may represent useful references for physicians to make dosing decisions.

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关键词

pharmacokinetics,cefepime,rational empirical dosing strategy,critically ill

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