Search
ChatPaper
AI Writing
analysis
Analysis
编组
Open Data
more
More
RankingsMust ReadingJournal&ConferenceAI TRAI HistoryMaster Reading TreeXiaomai's Star TalentsTrajectoryTalentNDI TrackerAI sign LanguageOpen
VIPCreated with Sketch.

Duvelisib Eliminates CLL B Cells, Impairs CLL-Supporting Cells, and Overcomes Ibrutinib Resistance in a Xenograft Model.

Shih-Shih Chen,Jacqueline C Barrientos,Gerardo Ferrer, Morgan King-Richards,Yu-Ju Chen,Priyadarshini Ravichandran,Michael Ibrahim,Yasmine Kieso, Sheila Waters,Jeffery L Kutok, Marisa Peluso,Sujata Sharma,David T Weaver,Jonathan A Pachter, Kanti R Rai, Nicholas Chiorazzi

Clinical cancer research : an official journal of the American Association for Cancer Research（2023）

Cited 0|Views19
No score
Abstract
Our data define the mechanism of action whereby dual inhibition of PI3K-δ,γ affects CLL B-cell numbers and T and myeloid cell pro-leukemia functions and support the use of duvelisib as a valuable approach for therapeutic interventions, including for patients refractory to BTKi.
More
Translated text
Key words
overcomes ibrutinib resistance,cll-supporting
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined