MicroRNA expression in extracellular vesicles as a novel blood-based biomarker for Alzheimer's disease.

Ashish Kumar,Yixin Su,Mitu Sharma,Sangeeta Singh,Susy Kim, Jeremy J Peavey,Cynthia K Suerken,Samuel N Lockhart,Christopher T Whitlow,Suzanne Craft,Timothy M Hughes,Gagan Deep

Alzheimer's & dementia : the journal of the Alzheimer's Association（2023）

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摘要

Multiple brain cell-derived small extracellular vesicles (sEVs) could be isolated simultaneously from blood. MicroRNA (miRNA) expression in sEVs could detect Alzheimer's disease (AD) with high specificity and sensitivity. miRNA expression in sEVs correlated with cortical region thickness on magnetic resonance imaging (MRI). Altered expression of miRNAs in sEV and sEV suggested vascular dysfunction. miRNA expression in sEVs could predict the activation state of specific brain cell types.

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关键词

Alzheimer's disease,biomarker,brain cells,extracellular vesicles,microRNA

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