CTLA4 prohibits T cells from cross-dressing.
The Journal of experimental medicine（2023）
Abstract
In this issue of JEM, Xiaozheng Xu et al. (2023. J. Exp. Med.https://doi.org/10.1084/jem.20221391) report that the inhibitory protein CTLA4 internalizes in cis the B7 stimulatory molecules previously "gnawed" by T cells from antigen-presenting cells (APCs) and in doing so prevents stimulatory T-T interactions.
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Key words
cells,cross-dressing
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