PD-L1 and PD-L2 Immune Checkpoint Protein Induction by Type III Interferon in Non-Small Cell Lung Cancer Cells

The type III IFN, IFN- λ, is capable of inducing PD-L1 and PD-L2 expression, at least in some NSCLC cells, and this regulation will need acknowledgment in the development of new diagnostic procedures, such as gene expression signature profiles, to improve PD-1/PD-1-ligand immunotherapy in NSCLC.