FOXA2 Cooperates with Mutant KRAS to Drive Invasive Mucinous Adenocarcinoma of the Lung.

Koichi Tomoshige,William D Stuart,Iris M Fink-Baldauf,Masaoki Ito,Tomoshi Tsuchiya,Takeshi Nagayasu,Tomoki Yamatsuji,Morihito Okada,Takuya Fukazawa,Minzhe Guo,Yutaka Maeda

Cancer research（2023）

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摘要

FOXA2 expression combined with mutant KRAS drives invasive mucinous adenocarcinoma of the lung by synergistically promoting a mucous transcriptional program, suggesting strategies for targeting this lung cancer type that lacks effective therapies.

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关键词

invasive mucinous adenocarcinoma,foxa2 cooperates,mutant kras

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