A translational pharmacokinetic/pharmacodynamic approach supports optimal vonoprazan dosing for erosive oesophagitis and Helicobacter pylori infection.

Carmelo Scarpignato,Colin W Howden,Eckhard Leifke,Darcy J Mulford,Gezim Lahu,Axel Facius,Richard Hunt

Alimentary pharmacology & therapeutics（2023）

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摘要

Vonoprazan 20 mg once- and twice-daily dosing demonstrated high, dose-dependent, 24-hour intragastric acid control in this PK/PD model, supporting clinical efficacy data in patients with acid-related disorders.

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关键词

optimal vonoprazan,pharmacokinetic/pharmacodynamic approach,<i>helicobacter pylori</i> infection,erosive oesophagitis,dosing

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