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MiR-199a-5P promotes osteogenic differentiation of human stem cells from apical papilla via targeting IFIT2 in apical periodontitis.

Jing Hu,Xia Huang,Liwen Zheng,Yuxin Zhang,Huan Zeng,Li Nie,Xiaoxiao Pang,Hongmei Zhang

Frontiers in immunology（2023）

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Abstract
These results strengthen our understanding of predictors and facilitators of the key AP miRNAs (miR-199a-5p) in bone lesion repair under periapical inflammatory conditions. And the regulatory networks will be instrumental in exploring the underlying mechanisms of AP and lay the foundation for future regenerative medicine based on dental mesenchymal stem cells.
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Key words
apical periodontitis,bone regeneration,human stem cells from apical papilla (hSCAPs),miR-199a-5p,microRNA,osteogenic differentiation
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