LRPPRC facilitates tumor progression and immune evasion through upregulation of m 6 A modification of PD-L1 mRNA in hepatocellular carcinoma.

Houhong Wang,Amao Tang,Yayun Cui,Huihui Gong,Heng Li

Frontiers in immunology（2023）

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摘要

This work unveiled that LRPPRC may posttranscriptionally upregulate PD-L1 partially with an mA-dependent manner for heightening mRNA stabilization of PD-L1 and provided a new mechanism for mA regulator-mediated immunosuppression in HCC.

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关键词

LRPPRC,PD-L1,anti-tumor immunity,hepatocellular carcinoma,immune evasion,m6A modification,tumor progression

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