C/EBPβ-LIP mediated activation of the malate-aspartate shuttle sensitizes cells to glycolysis inhibition.

Tobias Ackermann,Hidde R Zuidhof,Christine Müller,Gertrud Kortman,Martijn G S Rutten,Mathilde J C Broekhuis,Mohamad Amr Zaini,Götz Hartleben,Cornelis F Calkhoven

Molecular metabolism（2023）

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摘要

This study indicates that a low NADH/NAD+ ratio is an essential mediator of 2-deoxyglucose toxicity in cells with high cytoplasmic NAD-regeneration capacity and that simultaneous inhibition of glycolysis and lowering of the NADH/NAD ratio may be considered to treat cancer.

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关键词

C/EBPβ,Cancer,Glycolysis,Malate-aspartate shuttle,NAD(+)

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