New Mn(III)/Fe(III) complexes with thiohydantoin-supported imidazolium ionic liquids for breast cancer therapy

Ola A. Abu Ali,W. Abd El-Fattah,Mohammad Y. Alfaifi,Ali A. Shati,Serag Eldin I. Elbehairi,Ali H. Abu Almaaty,Reda F.M. Elshaarawy,Eman Fayad

Inorganica Chimica Acta（2023）

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摘要

•New thiohydantoin-imidazolium ionic liquids (THIMILs) and their complexes were prepared.•New compounds were characterized using elemental, spectral, and magnetic analyses.•Mn(III)THIMILs were square pyramidal, while and Fe(III)THIMILs were octahedral.•New hybrids inhibited MCF-7 cell proliferation more effectively than HepG2.•Fe(III)THIMIL analog (6b) was the most active and selective anti-MCF-7 agent.

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关键词

Thiohydantoin-Imidazolium hybrids,Mn(III)/Fe(III) complexes,Flow-cytometry,Anticancer activity

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