Immunity to pathogenic fungi in the eye.

Serena Abbondante,Sixto M Leal,Heather L Clark,Bridget Ratitong,Yan Sun,Li-Jun Ma,Eric Pearlman

Seminars in immunology（2023）

Cited 1|Views10

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Abstract

Fusarium, Aspergillus and Candida are important fungal pathogens that cause visual impairment and blindness in the USA and worldwide. This review will summarize the epidemiology and clinical features of corneal infections and discuss the immune and inflammatory responses that play an important role in clinical disease. In addition, we describe fungal virulence factors that are required for survival in infected corneas, and the activities of neutrophils in fungal killing, tissue damage and cytokine production.

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Key words

Aspergillus,Candida,Cornea,Cytokines,Fungal infection,Fusarium,IL-1 alpha,IL-1 beta,Innate immunity,Keratitis,NADPH oxidase,Neutrophil,Nutritional immunity,Ocular infection,Reactive oxygen species

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