Synthesis, characterization and molecular docking studies of highly selective new hydrazone derivatives of anthranilic acid and their ring closure analogue Quinazolin-4(3H)-ones against lung cancer cells A549
Journal of Molecular Structure(2023)
摘要
•New anthranilic acid hydrazones (3a-j) and quinazolin-4(3H)-ones (4a-j) were synthesized.•In vitro cytotoxic effects of compounds on A549 and BEAS-2B were evaluated.•Molecular docking study was performed using EGFR and VEGFR1 proteins.•It was determined that compound 3j was the most potent and selective agent in the series.
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关键词
Anthranilic acid,Quinazolin-4(3H)-one, Synthesis,Anticancer,Molecular docking
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