The role of additives on the interaction behavior of levofloxacin hemihydrate with crown ether: UV–visible spectroscopic and DFT techniques
Journal of Molecular Liquids(2023)
Abstract
•Interaction between crown ether (CE) and levofloxacin hemihydrate (LH) molecule has been studied.•Binding constant (Kb) of CE-LH complexes has been computed from Benesi-Hildebrand plot.•The CE-LH complexation is spontaneous and exothermic in nature.•DFT studies reveal the presence of strong interaction amongst the CE and LH drug.
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Key words
Crown ether,Levofloxacin hemihydrate,Binding constant (Kb),Thermodynamics,Density function theory (DFT)
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