Hyperammonemia induces microglial NLRP3 inflammasome activation via mitochondrial oxidative stress in hepatic encephalopathy.

So Yeong Cheon,Min-Yu Kim,Jeongmin Kim,Eun Jung Kim,Eun Hee Kam,Inja Cho,Bon-Nyeo Koo,So Yeon Kim

Biomedical journal（2023）

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摘要

Hyperammonemia in HE may be involved in mtROS overproduction and subsequent NLRP3 inflammasome activation. Further studies using NLRP3-specific inhibitor or NLRP knockout mice are needed to elucidate the important role of NLRP3 inflammasome in HE development.

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关键词

Bile duct ligation,Hepatic encephalopathy,Hyperammonemia,Microglia,NLRP3 inflammasome,Reactive oxygen species

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