Evidence of an Abnormal Mast Cell Marrow Compartment in Patients with Idiopathic Anaphylaxis

Patients presenting with anaphylaxis for unknown reasons and no clonal mast cell (MC) disease are diagnosed as having idiopathic anaphylaxis (IA) and exhibit elevations in total serum tryptase during episodes. It has been reported that patients with MC activation symptoms and elevated baseline tryptase associated with hereditary α-tryptasemia (HαT) exhibit unique bone marrow MC phenotypic and histologic changes. It is unknown whether patients with IA and/or IA/HαT have similar marrow morphology.