Infants with higher baseline spIgE to cow's milk make less progress on ladder-based tolerance induction programs

Infants with higher milk immunoglobulin E (IgE) levels are known to be less likely to tolerate baked milk. Previous work by our group has demonstrated the safety and efficacy of milk ladder use in IgE- mediated cow’s milk protein allergy (CMPA) in 60 infants less than 1 year of age at recruitment. We have examined the relationship of baseline spIgE to milk and milk components with progress up the 12 step iMAP milk ladder (MLP-milk ladder position) over 6 months.