Fructose Metabolism in Tumor Endothelial Cells Promotes Angiogenesis by Activating AMPK Signaling and Mitochondrial Respiration.

Jian-Hong Fang,Jie-Ying Chen,Jia-Lin Zheng,Hui-Xian Zeng, Jun-Guang Chen,Chen-Hui Wu,Jia-Li Cai,Zhi-Yong Wang,Shi-Mei Zhuang

Cancer research（2023）

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摘要

Fructose metabolism in endothelial cells fuels mitochondrial respiration to stimulate tumor angiogenesis, revealing fructose metabolism as a therapeutic target and fructose restriction as a dietary intervention for treating cancer.

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关键词

angiogenesis,mitochondrial respiration,ampk signaling

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