Synthesis, characterization, crystal structure, and cholinesterase inhibitory activity of 2-phenylthiazole derivatives
Journal of Molecular Structure（2023）
Abstract
•Design and synthesis of eighteen 2-phenylthiazole derivatives.•The new compounds were evaluated for cholinesterases inhibitory activity.•Compound 5a revealed the highest acetylcholinesterase inhibitory activity.•Molecular docking and molecular dynamics simulations study of compound 5a indicated that it interacted with PAS of AChE.
MoreTranslated text
Key words
Alzheimer's disease,Cholinesterase inhibitors,2-phenylthiazole derivatives,Aβ aggregation,Acetylcholinesterase
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined