In-depth proteomic analysis of juvenile dermatomyositis serum reveals protein expression associated with muscle-specific autoantibodies.

Hironori Sato,Yuzaburo Inoue,Yusuke Kawashima,Ryo Konno,Osamu Ohara,Masataka Kuwana,Norimoto Kobayashi,Shunichiro Takezaki,Shinji Akioka

Rheumatology (Oxford, England)（2023）

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摘要

Although JDM serum contains many proteins commonly altered in MSAs, the pathways associated with clinical features of MSAs differ based on protein accumulation. In-depth serum protein profiles associated with MSAs may be useful for developing therapeutic target molecules and biomarkers.

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关键词

Juvenile dermatomyositis,data independent acquisition-mass spectrometry proteomics,myositis-specific autoantibodies,proteasome,type 1 interferon

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