Impaired tolerance to the autoantigen LL-37 in acute coronary syndrome.

Fernando Chernomordik,Bojan Cercek,Jianchang Zhou,Xiaoning Zhao, Nicole Wai Man Lio,Kuang-Yuh Chyu,Prediman K Shah,Paul C Dimayuga

Frontiers in immunology（2023）

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摘要

Our report demonstrates that the immune response to the autoantigen LL-37 in ACS patients is characterized specifically by CD8+CD69+CD137+ T cell AIM profile with persistent T cell activation and the generation of immunologic memory. The results provide potentially novel insight into mechanistic pathways of antigen-specific immune signaling in ACS.

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关键词

LL-37,T cells,acute coronary syndrome,immune checkpoint,platelets,self-antigen

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