Spin and fragility in randomised controlled trials in the anaesthesia literature: a systematic review.

Achille Demarquette,Tristan Perrault,Thomas Alapetite,Madjid Bouizegarene,Romain Bronnert,Gaël Fouré,Charline Masson,Vivian Nicolas,Sigismond Lasocki,Maxime Léger

British journal of anaesthesia（2023）

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摘要

This systematic review showed that 40% of statistically negative trials in high-impact anaesthesia journals could mislead readers. For statistically positive RCTs, the results relied on few subjects, with a median fragility index of 4 [1-8]. Efforts must be continued to reduce spin and fragility in the medical literature.

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关键词

anaesthesia,fragility index,misleading reporting,quality of literature,reproducibility,spin,systematic review

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