Transmission of SARS-CoV-2 from Children and Adolescents

Victoria T. Chu,Anna R. Yousaf,Karen Chang,Noah G. Schwartz,Clinton J. McDaniel,Christine M. Szablewski,Marie Brown,Kathryn Winglee,Scott H. Lee,Zhaohui Cui, Adebola Adebayo, Tiffiany Aholou, Minal M. Amin,Peter Aryee, Cindy Castaneda, Trudy Chambers,Amy C. Fleshman, Christin Goodman, Tony Holmes, Asha Ivey-Stephenson, Emiko Kamitani, Susan Katz,Jennifer K. Knapp, Maureen Kolasa,Maranda Lumsden, Erin Mayweather,Asfia Mohammed,Anne Moorman, Alpa Patel-Larson, Lara Perinet, Mark Pilgard, Deirdre D. Pratt, Shanica Railey,Jaina Shah, Dawn Tuckey,Emilio Dirlikov,Dale A. Rose,Julie Villanueva,Alicia M. Fry,Aron J. Hall,Hannah L. Kirking,Jacqueline E. Tate,Cherie L. Drenzek,Tatiana M. Lanzieri,Rebekah J. Stewart

medrxiv(2020)

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摘要
A better understanding of SARS-CoV-2 transmission from children and adolescents is crucial for informing public health mitigation strategies. We conducted a retrospective cohort study among household contacts of primary cases defined as children and adolescents aged 7⍰19 years with laboratory evidence of SARS-CoV-2 infection acquired during an overnight camp outbreak. Among household contacts, we defined secondary cases using the Council of State and Territorial Epidemiologists definition. Among 526 household contacts of 224 primary cases, 48 secondary cases were identified, corresponding to a secondary attack rate of 9% (95% confidence interval [CI], 7%–12%). Our findings show that children and adolescents can transmit SARS-CoV-2 to adult contacts and other children in a household setting. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement This research was wholly supported by the U.S. Centers for Disease Control and Prevention. ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: This protocol was reviewed by CDC and the Georgia Department of Public Health human subjects research officials. The investigation was deemed non-research as part of the COVID-19 public health response. All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable. Yes Deidentified data to reproduce results will be available upon peer-reviewed publication and request.
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