Long term association between frailty and survival in patients with pleural disease

Introduction As the population ages, frailty is becoming more common and understanding how frailty impacts on patient outcomes has become an integral part of clinical care. To date, there is no evidence available on the relationship between frailty and patient outcomes in pleural disease. In this study we explore the relationship between frailty and both malignant and non-malignant pleural disease using the modified frailty index (mFI). Methods and Analysis Outpatients with pleural disease will be identified from a prospectively collected single-centre UK database and their data and notes retrospectively analysed. An mFI will be calculated for each patient and the correlation between their frailty index, final diagnosis and mortality analysed. Dissemination Study findings will be disseminated by publication in an appropriate journal and presentations at Respiratory and/or Geriatric medicine meetings. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement This study did not receive any funding. ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: Southmead Research Ethics Committee (initial application, March 2008) and South West - Central Bristol Research Ethics Committee (most recent amendment, April 2019) have given ethical approval for this work. I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable. Yes All data produced in the present study will be contained in the manuscript.