Differential T-cell and antibody responses induced by mRNA versus adenoviral vectored COVID-19 vaccines in patients with immunodeficiencies.

Ernest T Aguinam,Angalee Nadesalingam,Andrew Chan,Peter Smith,Minna Paloniemi,Diego Cantoni, Jessica Gronlund, Helen Gronlund,George W Carnell,Javier Castillo-Olivares,Nigel Temperton,Barbara Blacklaws,Jonathan L Heeney,Helen Baxendale

The journal of allergy and clinical immunology. Global（2023）

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摘要

Immunodeficient patients have impaired immune responses to mRNA and viral vector COVID-19 vaccines that appear to be influenced by vaccine formulation. Understanding the relative roles of T-cell- and antibody-mediated protection as well as the potential of heterologous prime and boost immunization protocols is needed to optimize the vaccination approach in these high-risk groups.

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关键词

BNT162b2,COVID-19,ChAdOx1-nCoV-19,SARS-CoV-2,T cells,antibodies,health care workers,immunodeficiency,immunoglobulins,vaccine

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