Highly sensitive tandem mass spectrometric measurement of serum estradiol without derivatization and pediatric reference intervals in children and adolescents.

Ashley Di Meo,Mehrdad Yazdanpanah,Victoria Higgins,Matthew Nichols,Mary Kathryn Bohn, Agnes Tan,Shazina Zainab,Lusia Sepiashvili,Khosrow Adeli

Clinical chemistry and laboratory medicine（2023）

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摘要

Our LC-MS/MS E2 assay shows acceptable accuracy, precision, functional sensitivity (LLoQ), and linearity for E2 quantification. Our LC-MS/MS E2 assay also showed good agreement with an external reference laboratory measuring E2 by LC-MS/MS. In addition, using CALIPER samples, we established robust age- and sex-specific pediatric E2 reference intervals to improve accuracy of test result interpretation and clinical decision making.

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关键词

LC-MS/MS,estradiol,immunoassay,pediatric,reference intervals

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