Venetoclax in combination with chemotherapy as treatment for pediatric advanced hematologic malignancies.
Pediatric blood & cancer(2023)
摘要
Venetoclax in combination with hypomethylating agents or cytotoxic chemotherapy was effective in a subset of pediatric/AYA patients with advanced hematologic malignancies, but multiple severe infections were observed, particularly among patients who received venetoclax in combination with chemotherapy. Prospective studies will be required to determine the optimal dose and duration of venetoclax in this population.
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关键词
adolescent and young adults,infection,leukemia,pediatric,venetoclax
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