The integrated stress response is activated in the salivary glands of Sjögren's syndrome patients.

Patricia Carvajal,Verónica Bahamondes,Daniela Jara,Isabel Castro,Soledad Matus,Sergio Aguilera,Claudio Molina,Sergio González,Marcela Hermoso,María-José Barrera,María-Julieta González

Frontiers in medicine（2023）

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Abstract

In summary, the results showed an increased ISR activation in LSGs of SS-patients. The increased protein levels of ATF4 and ATF4-target genes involved in the redox homeostasis could be part of a rescue response against the various stressful conditions to which the LSGs of SS-patients are subjected and promote cell survival.

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Key words

ATF4,Sjögren’s syndrome,acinar cells,integrated stress response,salivary glands

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