Urinary-derived extracellular vesicles reveal a distinct microRNA signature associated with the development and progression of Fabry nephropathy.
Frontiers in medicine(2023)
Abstract
The miRNA cargo in uEVs changes with the development and progression of Fabry nephropathy and, therefore, represents a potential biomarker that may provide a new option to prevent or attenuate the progression of nephropathy. Furthermore, dysregulated miRNAs were shown to be potentially associated with pathophysiological pathways in the kidney.
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Key words
Fabry disease,biomarker,longitudinal study,microRNA,nephropathy,urinary extracellular vesicles,urinary miRnome profiling
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