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Urinary-derived extracellular vesicles reveal a distinct microRNA signature associated with the development and progression of Fabry nephropathy.

Tina Levstek,Bojan Vujkovac,Andreja Cokan Vujkovac,Katarina Trebušak Podkrajšek

Frontiers in medicine（2023）

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Abstract
The miRNA cargo in uEVs changes with the development and progression of Fabry nephropathy and, therefore, represents a potential biomarker that may provide a new option to prevent or attenuate the progression of nephropathy. Furthermore, dysregulated miRNAs were shown to be potentially associated with pathophysiological pathways in the kidney.
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Key words
Fabry disease,biomarker,longitudinal study,microRNA,nephropathy,urinary extracellular vesicles,urinary miRnome profiling
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