Extranodal marginal zone lymphoma clonotypes are detectable prior to eMZL diagnosis in tissue biopsies and peripheral blood of Sjögren's syndrome patients through immunogenetics.

P Martijn Kolijn,Erika Huijser,M Javad Wahadat,Cornelia G van Helden-Meeuwsen,Paul L A van Daele,Zana Brkic,Jos Rijntjes,Konnie M Hebeda,Patricia J T A Groenen,Marjan A Versnel,Rogier M Thurlings,Anton W Langerak

Frontiers in oncology（2023）

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摘要

In conclusion, our results indicate that eMZL clonotypes in pSS patients are detectable prior to overt eMZL diagnosis in both tissue biopsies and peripheral blood through immunogenetic sequencing, paving the way for the development of improved methods of early detection of eMZL.

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关键词

Sjögren’s syndrome,early detection,immunogenetics,lymphoma,lymphomagenesis

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