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Untargeted metabolomics profiling in pediatric patients and adult populations indicates a connection between lipid imbalance and epilepsy.

Kaisa Teele Oja,Mihkel Ilisson,Karit Reinson,Kai Muru,Tiia Reimand,Hedi Peterson,Dmytro Fishman,Tõnu Esko,Toomas Haller,Jaanika Kronberg,Monica H Wojcik,Adam Kennedy,Gregory Michelotti,Anne O'Donnell-Luria,Eve Õiglane-Šlik,Sander Pajusalu,Katrin Õunap

medRxiv : the preprint server for health sciences（2023）

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Abstract
Our results suggest that cell membrane fluidity may have a significant role in the mechanism of epilepsy, and changes in lipid balance may indicate epilepsy. However, further studies are needed to evaluate whether untargeted metabolomics analysis could prove helpful in diagnosing epilepsy earlier.
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