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Immune and ionic mechanisms mediating the effect of dexamethasone in severe COVID-19.

Ameet A Chimote,Abdulaziz O Alshwimi,Martina Chirra,Vaibhavkumar S Gawali,Margaret V Powers-Fletcher,Kristin M Hudock,Laura Conforti

Frontiers in immunology（2023）

Cited 2|Views12
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Abstract
Our findings suggest that dexamethasone attenuates inflammatory cytokine release via Kv1.3 suppression, and this mechanism contributes to dexamethasone-mediated immunosuppression in severe COVID-19.
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Key words
COVID-19,cytokine storm,dexamethasone,interferon signaling,ion channels,severe COVID-19,severe COVID-19 immune signaling
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