Inhibition of TANK-binding kinase1 attenuates the astrocyte-mediated neuroinflammatory response through YAP signaling after spinal cord injury.
CNS neuroscience & therapeutics(2023)
Abstract
TBK1-medicated innate immune pathway in astrocytes through YAP signaling plays an important role in the pathogenesis of SCI and inhibition of TBK1 may be a potential therapeutic drug for SCI.
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Key words
TBK1,YAP,amlexanox,astrocytes,noncanonical NF-κB signaling pathway,spinal cord injury
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