Can neurological soft signs and neurocognitive deficits serve as a combined endophenotype for Han Chinese with bipolar disorder?

Yingying Feng,Jia Song,Guorong Lin,Hong Qian,Li Feng,Zongqin Wang,Juan Wen,Chengchen Wang,Jiayuan Wang,Peifu Li,Zuohui Gao,Xiaoli Wang,Xiaohua Hu

International Journal of Methods in Psychiatric Research（2023）

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Abstract

These results provide more evidence that motor coordination, IPS, VL, and WM may be internal characteristics of bipolar disease. When these characteristics are combined into a complex endophenotype, it may be possible to distinguish BD patients and high-risk groups from normal populations.

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Key words

bipolar disorder,endophenotype,information processing speed,neurocognitive deficits,neurological soft signs,verbal learning,working memory

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