Process optimization and techno-economic analysis for the production of lipase from Bacillus sp.
Journal of Taibah University for Science(2023)
Abstract
Lipases are widely used in many biochemical industries. Media optimization is considered one of the best ways to produce a large quantity of lipase economically. This study used Response Surface Methodology (D - Optimal design in MODDE 13 to comprehend the effect of different media on the enzyme activity. The enzyme activity was highest under the following conditions: 10.1 g/L of peptone, 7.5 g/L of Yeast Extract, and 13.9 mL/L of Olive oil. A feasibility analysis of lipase production from the microbes using the optimized data was performed, and at optimized conditions, lipase activity increased from 0.757 mu mol/min to 0.959 mu mol/min. A simulation study for large-scale batch production for lipase was conducted using SuperPro Designer (v10), and techno-economic data was analyzed. The expected cost per unit volume of lipase was estimated to be 4393.96 $. Thus, process optimization with technoeconomic analysis could be helpful for industrial-scale lipase production.
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Key words
Lipase,techno-economic analysis,optimization,enzyme activity,RSM
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