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Critical Role of Insulin as an Immunomodulatory Target in Treatment Resistant Depression

Susannah Tye,Joshua Price,Adam Walker,Shari Sutor,Sophie Erhardt,Lilly Schwieler,Kathryn Cullen,Jennifer Vande Voort,Mark Frye,William Bobo,Paulo Shiroma

Biological Psychiatry（2023）

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Abstract
The mechanisms governing poor antidepressant response in treatment-resistant depression (TRD) are not known. We investigated the critical role of insulin as a a moderator of immune response and antidepressant outcomes in a rodent model and human subjects.
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Key words
Ketamine,Treatment Resistant Depression,Insulin,Immunometabolism,Inflammation
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