343. Effects of Natural and Experimental Withdrawal From Estradiol or Progesterone on Stop-Signal Inhibition Across the Menstrual Cycle in Patients With Suicidal Ideation

Our recent experimental work shows that the menstrual cycle can affect suicidality with perimenstrual withdrawal from combined estradiol/E2 and progesterone/P4, or E2 alone, causing increases in proximal suicide risk. In this study, we investigate whether these hormone withdrawal effects on suicidality are mirrored in changes to inhibitory control.