489. Gender-Based Gene Expression Changes in Human and Rat Brains With a History of Nicotine Exposure

Chronic nicotine exposure induced changes in the expression of key gender regulatory genes associated with metabolic function and neuronal alterations. Many bioregulatory genes have been associated with exposure to nicotine, but the modulating effects of sex on gene expression in nicotine-exposed brains have been largely unexplored. Research comparing pre-clinical models with human subjects provides an important opportunity to understand common biomarkers of the harmful effects of nicotine.