26. Adjunctive Simvastatin for Treatment-Resistant Depression: A Randomized Clinical Trial

Muhammad Ishrat Husain,Imran Chaudhry,Ameer Bukhsh Khoso,Tayyeba Kiran,Nawaz Khan,Farooq Ahmad,John Hodsoll,Muhammad Omair Husain,Haider Ali Naqvi,Asad Tamizuddin Nizami,Nasim Chaudhry, Hazrat Ali Khan,Fareed Minhas,Jeffrey H. Meyer,Moin Ansar,Benoit H. Mulsant,Nusrat Husain,Allan H. Young

Biological Psychiatry（2023）

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摘要

Preliminary trials suggest that statins may be useful adjunctive treatments for depression. This 12-week RCT, conducted in five centres in Pakistan, aimed to assess the efficacy and tolerability of adjunctive simvastatin compared to placebo for reduction of depressive symptoms in treatment-resistant depression (TRD).

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关键词

adjunctive simvastatin,depression,treatment-resistant

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