248. Effects of NMDA Receptor Antagonist Ketamine on Neural Tuning

Glutamatergic neurotransmission mediated by N-methyl-D-aspartate receptors (NMDAR) is critical for cortical computations underlying cognition; associated disruptions are hypothesized to underlie psychosis spectrum disorders(PSD). Cortical microcircuit models hypothesize that NMDAR disinhibition facilitates impaired cognition in PSD by weakening neural tuning. However, the mechanisms explaining the relationship between altered microcircuit tuning and system-level neural dynamics, specifically in humans, have yet to be studied.